What does "SSIS uses the package configuration to update the values of properties within packages at run time" mean?
Save the package configuration to Environment Variables
Create environment variables:ConnectStr and MyFile

Create an SSIS project;

Create a Package Configuration

After the configuration, value of environment variable ConnectStr will replace the ConnectionString target property; The value of environment variable MyFile will replace the Arguments of Execute Process Task.
Your package will execute against different values when the values of Environment variables change.